Bright Fluorescence

Endothelial Specific Marker 1 (ESM-1)

Endothelial cell-specific molecule (ESM-1), also called endocan, is a biomarker of vascular endothelial activation/dysfunction in diseases. This proteoglycan is constitutively produced by endothelial cells, is increased during inflammation and involved in a wide range of biological processes such as proliferation, migration, cell adhesion and neovascularization.

The variation of blood levels of ESM-1 may reflect endothelial dysfunction in several pathological conditions, including sepsis, cancer, dengue fever, respiratory failure, obesity, and preeclampsia.

The ESM-1 Pregnostic®-PE IIp ELISA is to be used for research use only (RUO).

Pregnostic®–PE IIp ELISA
A kit for the measurement of plasma ESM-1 concentrations

Special features

  • Complete ELISA kit with pre-coated plates
  • Rapid assay, takes less than 5 hours, less than 1 hour of hands-on-time
  • Quantification of the ESM-1 in plasma or in human cell culture supernatants
  • Ready to use assay
  • For research use only. Not for use in diagnostic procedures.

Pregnostic®-PE IIp contains all components required for quantification of human ESM-1 in cell culture supernatants or plasma. This human Pregnostic®-PE IIp ELISA set uses the robust and well-described quantitative sandwich immunoassay technique. The kit is available for research purposes. The performance characteristics of this kit have not completely established yet.

ESM-1 Pregnostic®-PE IIp ELISA
Product code: IQP-304

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Package Insert Pregnostic ®-PE IIp ELISA

Safety Data Sheet Pregnostic®-PE IIp ELISA


Schuitemaker, J.H.N., et al., Changes in endothelial cell specific molecule 1 plasma levels during preeclamptic pregnancies compared to healthy pregnancies. Pregnancy Hypertens, 2018. 12: p. 58-64.

Stéphane, S., et al., Endocan as a Biomarker of Endothelial Dysfunction in Cancer. Journal of Cancer Science & Therapy, 2010. 02(02): p. 47-52.

Chang, X., et al., Endocan of the maternal placenta tissue is increased in pre-eclampsia. Int J Clin Exp Pathol 2015. 8(11): p. 14733-14740.

Adekola, H., et al., Endocan, a putative endothelial cell marker, is elevated in preeclampsia, decreased in acute pyelonephritis, and unchanged in other obstetrical syndromes. J Matern Fetal Neonatal Med, 2015. 28(14): p. 1621-32.

Cakmak, M., et al., Serum levels of endocan correlate with the presence and severity of pre-eclampsia. Clin Exp Hypertens, 2016. 38(2): p. 137-42.

Hentschke, M.R., et al., Endocan-1 concentrations in maternal and fetal plasma and placentae in pre-eclampsia in the third trimester of pregnancy. Cytokine, 2015. 74(1): p. 152-6.

De Freitas Caires, N., et al., Endocan, sepsis, pneumonia, and acute respiratory distress syndrome. Crit Care, 2018. 22(1): p. 280.

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