Pregnostic®-PE Ip

A kit for the prediction of risk to develop Pre-Eclampsia (PE)

Special features

  • Complete ELISA kit
  • Rapid assay, takes less than 3 hours, less than 1 hour of hands-on-time
  • Standardized and quantitative
  • Quantification of the PE-biomarker in biological fluids (sera, plasma) or in human cell culture supernatants
  • Pre-coated ELISA plates
  • Ready to use assay
  • RUO

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If you are interested in the Pregnostic®-PE Ip for research purposes in cooperation with IQ Products, please contact us!


Endothelial cell-specific molecule (ESM-1) is a unique and pertinent biomarker of vascular endothelial activation/dysfunction in diseases. The variation of blood levels of ESM-1 may reflect endothelial dysfunction in several pathological conditions, including sepsis, cancer, dengue fever and obesity 1. Higher ESM-1 levels are also related to occurrence of pre-eclampsia in pregnancy 3-6. Moreover, ESM-1 levels are significantly lower in pregnant women that develop severe early-onset pre-eclampsia at week 12 of gestation 2, hereby, providing a useful biomarker for the assessment of the risk to develop pre-eclampsia. Early assessment of the risk for pre-eclampsia can provide an opportunity for accurate management during pregnancy to limit harm to the unborn child.

Product specifications

Pregnostic®-PE Ip contains all components required for quantification of human ESM-1 in cell culture supernatants, serum or plasma. This human Pregnostic®-PE Ip ELISA set uses the robust and well-described quantitative sandwich immunoassay technique. The kit is available for research purposes in cooperation with IQ Products. The performance characteristics of this kit have not completely established yet.


  1. Sarrazin et al. (2010) J. Cancer Sci. Ther. 2: 47-52
  2. J. Schuitemaker et al. (manuscript submitted)
  3. Chang et al. (2015) Endocan of the maternal placenta tissue is increased in pre-eclampsia. Int J Clin Exp Pathol. 8(11): 14733-14740
  4. Adekola et al. (2015) Endocan, a putative endothelial cell marker, is elevated in preeclampsia, decreased in acute pyelonephritis, and unchanged in other obstetrical syndromes. J Matern Fetal Neonatal Med. 28(14):1621-1632
  5. Cakmak et al. (2016) Clin Exp Hypertens. 38(2): 137-142
  6. Hentschke et al. (2015) Endocan-1 concentrations in maternal and fetal plasma and placentae in pre-eclampsia in the third trimester of pregnancy. Cytokine. 74: 152-156

Safety Data Sheet


Package Insert


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