Macro163 ELISA

Macro163 ELISA

Co-developed by IQ Products and Trillium Diagnostics

A unique product!

CD163 is a membrane protein and member of the group B Scavenger Receptor Cysteine-Rich super family specifically expressed on peripheral blood monocytes and macrophages. A particularly high expression is seen in macrophages of the 'alternative activation' phenotype playing a major role in dampening the inflammatory response and in scavenging components of damaged cells.

CD163 functions as the receptor for Haptoglobin-hemoglobin complexes, and furthermore CD163 is involved in the regulation of inflammation. Macrophages play a central role in the host response to infection and tissue damage, and are furthermore important in the pathogenesis of autoimmune diseases and cancer.

Historically, the presence of CD163 (by immunhistochemistry) has been associated with a post-infectious recovery phase and declining inflammation. CD163 positive macrophages constitute a major cell subpopulation in human term placenta suggesting a role for the placenta functioning as an active immunosuppressive biological barrier between mother and fetus. Importantly, the extracellular part of CD163 is cleaved from the cell-membrane by proteolytic activity upon toll-like receptor activation. This shed CD163 molecule (soluble CD163, sCD163) is detectable in body fluid compartments and is regarded to reflect activation and proliferation of macrophages in inflammatory conditions.Measurement of sCD163 may be a valuable marker in diseases with macrophage and/or monocyte involvement, such as macrophage activation syndromes (e.g. hemophagocytic syndrome), infections, liver disease, auto-immune disease, atherosclerosis and cancer.

Unique features!